pupsc removal

[camelv]

i have removed pupsc threats from my desktop and laptop computers ,my desktop is running win xp and lappy is running vista and i used mbam and spybot to get rid of them.
i have now tried to do the same on my brothers lappy which is a dell running vista ,when i scan with mbam no threats are found but when i scan with spybot there are pupsc threats on it and spybot will not remove them .any one any ideas .
thanks cam

[smoggy]

according to a spybot advisor, pups stands for potentially unwanted programs
does it give any indication of any programs etc. in the threat message

[camelv]

according to a spybot advisor, pups stands for potentially unwanted programs
does it give any indication of any programs etc. in the threat message

Also when i try to use immunize on spy bot its saying that there is a browser running, but i dont know how to disable i.

[smoggy]

it could be or associated with one of your browser toolbars
Have you tried running spybot in safe mode